THE AMOUNT, ECONOMIC VALUE AND ENVIRONMENTAL EMISSION OF CEPHAPIRIN AT DRY-OFF IN HOLSTEIN AND SIMMENTAL DAIRY COWS BY HERD SIZE

Authors

  • Boris Ljubojević Croatian Forests Ltd., Directorate, Ulica kneza Branimira 1, 10000 Zagreb, Croatia
  • Ranko Gantner Faculty of Agrobiotechnical Sciences Osijek, J.J. Strossmayer University of Osijek, Vladimira Preloga 1, Osijek, 31000, Croatia
  • Zvonimir Steiner Faculty of Agrobiotechnical Sciences Osijek, J.J. Strossmayer University of Osijek, Vladimira Preloga 1, Osijek, 31000, Croatia
  • Dragan Solić Croatian Agency for Agriculture and Food, Vinkovačka cesta 63c, Osijek, 31000, Croatia
  • Vesna Gantner Faculty of Agrobiotechnical Sciences Osijek, J.J. Strossmayer University of Osijek, Vladimira Preloga 1, Osijek, 31000, Croatia

DOI:

https://doi.org/10.59267/ekoPolj25041343L

Keywords:

mastitis, selective dry cow therapy, cephapirin, environmental antibiotic emission, herd size

Abstract

The research aim was to quantify the use of cephapirin in dry cow therapy, to estimate the economic value and potential environmental emissions regarding the herd size. The analysis included a 307,531 test-day records from Holsteins and 383,208 from Simmental. Udder health status at the last milk recording before dry-off was classified according to SCC criteria, and the scenario assumed universal use of BDCT, 1.2 g cephapirin per cow (300 mg per quarter × 4). The estimated total amount of cephapirin was 369.0 kg in Holsteins and 459.8 kg in Simmentals. The economic cost of the application was €7.85 million in Holstein and €9.78 million in Simmental herds, with healthy cows generating the largest share of the cost due to their large numbers. The estimated environmental release was 221.4 kg for Holstein and 275.9 kg for Simmental, with PEC/PNEC ratios high above the risk threshold, RQ 4,428.41 and 5,518.19, respectively.

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References

Ajulo, S., & Awosile, B. (2024). Global antimicrobial resistance and use surveillance system (GLASS 2022): Investigating the relationship between antimicrobial resistance and antimicrobial consumption data across the participating countries. PLOS ONE, 19(2), e0297921. https://doi.org/10.1371/journal.pone.0297921

Beggs, D. S., Jongman, E. C., Hemsworth, P. H., & Fisher, A. D. (2019). The effects of herd size on the welfare of dairy cows in a pasture-based system using animal- and resource-based indicators. Journal of Dairy Science, 102(4), 3406– 3420. https://doi.org/10.3168/jds.2018-14850

Bengtsson-Palme, J., & Larsson, D. G. J. (2016). Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environment International, 86, 140–149. https://doi.org/10.1016/j.envint.2015.10.015

Berendsen, B. J. A., Wegh, R. S., Memelink, J., Zuidema, T., & Stolker, L. A. M. (2015). The analysis of animal faeces as a tool to monitor antibiotic usage. Talanta, 132, 258–268. https://doi.org/10.1016/j.talanta.2014.09.022

Cortinhas, C. S., Oliveira, L., Hulland, C. A., Santos, M. V., & Ruegg, P. L. (2013). Minimum inhibitory concentrations of cephalosporin compounds and their active metabolites for selected mastitis pathogens. American Journal of Veterinary Research, 74(5), 683–690. https://doi.org/10.2460/ajvr.74.5.683

European Chemicals Agency (ECHA). (2024). Cephapirin sodium – Registration Dossier. Retrieved from https://echa.europa.eu/registration-dossier/-/registereddossier/29333

Filippone Pavesi, L.; Pollera, C.; Sala, G.; Cremonesi, P.; Monistero, V.; Biscarini, F.; Bronzo, V. Effect of the Selective Dry Cow Therapy on Udder Health and Milk Microbiota. Antibiotics 2023, 12, 1259. https://doi.org/10.3390/antibiotics12081259

Gantner, V., Šinka, D., Popović, V., Ćosić, M., Sudarić, T., & Gantner, R. (2023). The variability of microclimate parameters in dairy cattle farm facility. In Sustainable agriculture and rural development: Thematic proceedings of the III international scientific conference, December 2022, Belgrade (pp. 77–86). Institute of Agricultural Economics. https://www.iep.bg.ac.rs

Green, M. J., Green, L. E., Medley, G. F., Schukken, Y. H., & Bradley, A. J. (2002). Influence of Dry Period Bacterial Intramammary Infection on Clinical Mastitis in Dairy Cows. Journal of Dairy Science, 85(10), 2589–2599. https://doi.org/10.3168/jds.S0022-0302(02)74343-9

Guadagnini, M., Gogna, C., Tolasi, C., Tolasi, G., Gnali, G., Freu, G., Masroure, A. J., & Moroni, P. (2023). Approach to Selective Dry Cow Therapy in Early Adopter Italian Dairy Farms: Why Compliance Is So Important. Animals, 13(22), 3485. https://doi.org/10.3390/ani13223485

Halasa, T., Huijps, K., Østerås, O., & Hogeveen, H. (2007). Economic effects of bovine mastitis and mastitis management: A review. Veterinary Quarterly, 29(1), 18–31. https://doi.org/10.1080/01652176.2007.9695224

Kharel, M., Timisina, K. P., Adhikari, S. P., Dhakal, C., Khanal, D. R., & Paudel, T. P. (2023). Does mastitis cause economic loss in dairy cattle in Nepal? Nepal Agriculture Research Journal, 15(1), 55–65. https://doi.org/10.3126/narj.v15i1.51064

Krogh, M. A., Nielsen, C. L., & Sørensen, J. T. (2020). Antimicrobial use in organic and conventional dairy herds. Animal, 14(10), 2187–2193. https://doi.org/10.1017/S1751731120000920

Kupczyński, R., Bednarski, M., Sokołowski, M., Kowalkowski, W., & Pacyga, K. (2024). Comparison of Antibiotic Use and the Frequency of Diseases Depending on the Size of Herd and the Type of Cattle Breeding. Animals, 14(13), 1889. https://doi.org/10.3390/ani14131889

Lipkens, Z.; Piepers, S.; De Vliegher, S. Impact of Selective Dry Cow Therapy on Antimicrobial Consumption, Udder Health, Milk Yield, and Culling Hazard in Commercial Dairy Herds. Antibiotics 2023, 12, 901. https://doi.org/ 10.3390/antibiotics120509011

Maksimović, Z., Čengić, B., Ćutuk, A., & Maksimović, A. (2024). Antimicrobial Resistance of Cattle Mastitis-Causing Bacteria: How to Treat? In K. Petrovski (Ed.), Veterinary Medicine and Science (Vol. 19). IntechOpen. https://doi.org/10.5772/intechopen.112977

McCubbin, K. D., De Jong, E., Brummelhuis, C. M., Bodaneze, J., Biesheuvel, M., Kelton, D. F., Uyama, T., Dufour, S., Sanchez, J., Rizzo, D., Léger, D., & Barkema, H. W. (2023). Antimicrobial and teat sealant use and selection criteria at dry-off on Canadian dairy farms. Journal of Dairy Science, 106(10), 7104–7116. https://doi.org/10.3168/jds.2022-23083

Medical Intertrade d.o.o. (2025). Ponuda za antibiotike: Mastidry, Cefa-Safe, Orbeseal, Keraseal (Ponuda br. 12379/2025, 12. lipnja 2025.). Zagreb: Medical Intertrade d.o.o.

Müller, S., Nitz, J., Tellen, A., Klocke, D., & Krömker, V. (2023). Effect of Antibiotic Compared to Non-Antibiotic Dry Cow Treatment on the Bacteriological Cure of Intramammary Infections during the Dry Period—A Retrospective Cross-Sectional Study. Antibiotics, 12(3), 429. https://doi.org/10.3390/antibiotics12030429

Navaei, H., Vodjgani, M., Khoramian, B., Akbarinejad, V., Gharagozloo, F., Garoussi, M. T., & Momeni, A. (2025). Evaluation of a new method of selective dry cow treatment using microbiological culture and antibiogram results. BMC Veterinary Research, 21(1). https://doi.org/10.1186/s12917-025-04767-z

Očić, V., Bobić Šakić, B., & Grgić, Z. (2022). Economic analysis of specialized dairy farms in Croatia according to FADN. Mljekarstvo, 73(1), 50–58. https://doi.org/10.15567/mljekarstvo.2023.0106

Peña-Mosca, F., Gaire, T. N., Dean, C., Ferm, P., Manriquez, D., Pinedo, P., Noyes, N., & Caixeta, L. (2025). Exploring the phylogenetic diversity and antimicrobial activity of non-aureus staphylococci and mammaliicocci isolated from teat apices of organic dairy cows. bioRxiv 2024.02.01.578391; https://doi.org/10.1101/2024.02.01.578391

Popescu, G., & Andrei, J. (2011). From industrial holdings to subsistence farms in Romanian agriculture. Analyzing the subsistence components of CAP. Agricultural Economics, 57(11), 555.

Ribeiro, A. R., Sures, B., & Schmidt, T. C. (2018a). Cephalosporin antibiotics in the aquatic environment: A critical review of occurrence, fate, ecotoxicity and removal technologies. Environmental Pollution, 241, 1153–1166. https://doi.org/10.1016/j.envpol.2018.06.040

Ribeiro, A. R., Sures, B., & Schmidt, T. C. (2018b). Ecotoxicity of the two veterinarian antibiotics ceftiofur and cefapirin before and after phototransformation. Science of The Total Environment, 619–620, 866–873. https://doi.org/10.1016/j.scitotenv.2017.11.109

Rowe, S. M., Godden, S. M., Nydam, D. V., Gorden, P. J., Lago, A., Vasquez, A. K., Royster, E., Timmerman, J., & Thomas, M. J. (2020). Randomized controlled trial investigating the effect of 2 selective dry-cow therapy protocols on udder health and performance in the subsequent lactation. Journal of Dairy Science, 103(7), 6493–6503. https://doi.org/10.3168/jds.2019-17961

Seegers, H., Fourichon, C., & Beaudeau, F. (2003). Production effects related to mastitis and mastitis economics in dairy cattle herds. Veterinary Research, 34(5), 475–491. https://doi.org/10.1051/vetres:2003027

Smith, J. W., Ely, L. O., & Chapa, A. M. (2000). Effect of Region, Herd Size, and Milk Production on Reasons Cows Leave the Herd. Journal of Dairy Science, 83(12), 2980–2987. https://doi.org/10.3168/jds.S0022-0302(00)75198-8

Stocco, G., Cipolat-Gotet, C., Stefanon, B., Zecconi, A., Francescutti, M., Mountricha, M., & Summer, A. (2023). Herd and animal factors affect the variability of total and differential somatic cell count in bovine milk. Journal of Animal Science, 101, skac406. https://doi.org/10.1093/jas/skac406

Stockler, R. M., Morin, D. E., Lantz, R. K., & Constable, P. D. (2009). Effect of milking frequency and dosing interval on the pharmacokinetics of cephapirin after intramammary infusion in lactating dairy cows. Journal of Dairy Science, 92(9), 4262–4275. https://doi.org/10.3168/jds.2008-1916

Tell, J., Caldwell, D. J., Häner, A., Hellstern, J., Hoeger, B., Journel, R., Mastrocco, F., Ryan, J. J., Snape, J., Straub, J. O., & Vestel, J. (2019). Science-based Targets for Antibiotics in Receiving Waters from Pharmaceutical Manufacturing Operations. Integrated Environmental Assessment and Management, 15(3), 312–319. https://doi.org/10.1002/ieam.4141

Thiele‐Bruhn, S. (2003). Pharmaceutical antibiotic compounds in soils – a review. Journal of Plant Nutrition and Soil Science, 166(2), 145–167. https://doi.org/10.1002/jpln.200390023

Tomanić, D., Samardžija, M., Stančić, I., Kladar, N., Maćešić, N., & Kovačević, Z. (2024). Mastitis challenges in Serbian dairy farming: A study on somatic cell counts and pathogen distribution. Mljekarstvo, 239–248. https://doi.org/10.15567/mljekarstvo.2024.0307

Vanhoudt, A., Hees-Huijps, K. van, Knegsel, A. T. M. van, Sampimon, O. C., Vernooij, J. C. M., Nielen, M., & Werven, T. van. (2018). Effects of reduced intramammary antimicrobial use during the dry period on udder health in Dutch dairy herds. Journal of Dairy Science, 101(4), 3248–3260. https://doi.org/10.3168/jds.2017-13555

Vissio, C., Richardet, M., Issaly, L. C., & Larriestra, A. J. (2023). Decision making on dry cow therapy: Economic evaluation using field data under Argentinian production conditions. Ciência e Agrotecnologia, 47, e016322. https://doi.org/10.1590/1413-7054202347016322

Weber, J., Borchardt, S., Seidel, J., Schreiter, R., Wehrle, F., Donat, K., & Freick, M. (2021). Effects of Selective Dry Cow Treatment on Intramammary Infection Risk after Calving, Cure Risk during the Dry Period, and Antibiotic Use at DryingOff: A Systematic Review and Meta-Analysis of Current Literature (2000–2021). Animals, 11(12), 3403. https://doi.org/10.3390/ani111234036

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Published

2025-12-22

How to Cite

Ljubojević, B. ., Gantner, R. ., Steiner, Z. ., Solić, D. ., & Gantner, V. (2025). THE AMOUNT, ECONOMIC VALUE AND ENVIRONMENTAL EMISSION OF CEPHAPIRIN AT DRY-OFF IN HOLSTEIN AND SIMMENTAL DAIRY COWS BY HERD SIZE. Economic of Agriculture, 72(4), 1343–1358. https://doi.org/10.59267/ekoPolj25041343L

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Original scientific papers